ChemDIV JHU100K Library (2019 Newly purchased)
Compounds were cherry-picked from ChemDIV diverse collection based on JHU’s requirements mainly on:
– MW closer to 400,
– lower LogP (median around 3),
– and more H-bond donors.
For HTS cost-saving, 10,000 compounds (10%) are picked from this collection with maximized diversity as an optional set.
Download structure sd file for ChemDiv10K384Well
John Hopkins Drug Library (JHDL)
The Johns Hopkins Drug Library (JHDL) contains 1,900 FDA approved, 600 foreign-approved drugs and 800 valuable but not approved compounds available in 96-well (32 plates) and 384-well format (8 plates) in 5 mM stock or 200uM diluted concentration.
MSSP (Spectrum 1)
Library MSSP was purchased from MicroSource Discovery Inc. (Groton, CT). It contains 2,000 compounds on 25 plates, 80 compounds per plate. The columns on the right and left sides of each plate (columns 1 and 12) contain DMSO only. The plates are labeled 1-25.
In the master plates, each compound is suspended in DMSO at a concentration of 10mM. The average molecular weight of the compounds is 350 g/mol. Plates diluted to 2 mM or 0.1 mM are considered 200X or 10X, respectively.
The library contains known bioactive compounds and natural products and their derivatives.
Sigma LOPAC 1280
Library LOPAC 1280 was purchased from Sigma-Aldrich. It contains 1,280 compounds on 16 96-well plates, 80 compounds per plate. In the master plates, each compound is suspended in DMSO at a concentration of 10mM.
The library contains pharmacologically active compounds for all major target classes, such as GPCRs and kinases. Some of them are marketed drugs. Each of the compounds is available as individual item from Sigma-Aldrich catalog, permitting rapid and guaranteed assess of compounds in follow-up experiments.
ChemBridge CNS-Set
The CNS-Set library ( 50,000 compounds) was developed to facilitate the exploration of compounds which would be more likely to pass the blood brain barrier. The library has a log P between 0-5, a lower molecular weight limit (190-500 instead of 170-700), and utilizes our internal Medicinal Chemistry expertise for hand selecting compounds as well as Chem-X software for pharmacophore diversity quantification. This library is useful not only for CNS therapeutic targets, where a compound’s ability to pass the blood brain barrier is critical, but also for general screening conditions where Lipinsky Rule of Five considerations may be important.
ChemBridge Diver-SET
The DIVERSet library ( 50,000 compounds) is designed as a universal screening library, covering the broadest part of pharmacophore diversity space with the minimum number of compounds. This substantially cuts discovery timescales and cost by reducing the number of compounds that need to be tested. DIVERSet is particularly useful for primary screening against a wide range of biological targets, including those where no structural information is available.
NIH Full Library
The NIH library ( 300,000 compounds) is available for qualified project. Contact us for details: info@hopkinschemcore.org